Preoperative Erythropoietin Administration in Patients With Prostate Cancer Undergoing Radical Prostatectomy Without Transfusion
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À̺´¿ì(Lee Byung-Woo) - Inje University Seoul Paik Hospital Department of Urology
¹Ú¼®»ê(Park Seok-San) - Inje University Haeundae Paik Hospital Departments of Urology
¿©Á¤±Õ(Yeo Jeong-Kyun) - Inje University Seoul Paik Hospital Department of Urology
¹Ú¹Î±¸(Park Min-Gu) - Inje University Seoul Paik Hospital Department of Urology
Á¶´ë¿¬(Cho Dae-Yeon) - Inje University Seoul Paik Hospital Department of Urology
Abstract
Purpose: In this study, we administered erythropoietin preoperatively to patients who underwent open radical prostatectomy without transfusion to increase their hemoglobin levels and investigated the efficacy of this procedure.
Materials and Methods: We evaluated 62 patients who underwent open radical prostatectomy performed by the same surgeon between June 2005 and January 2011. The 22 patients who refused transfusion were assigned to group 1; the patients who accepted transfusion were assigned to group 2. Before surgery, we administered erythropoietin beta to group 1 patients whose hemoglobin levels were <12 g/dL and retrospectively compared the clinical data of the two groups. We used the t-test and the chi-square test for statistical analysis.
Results: Mean preoperative hemoglobin levels in group 1 after erythropoietin administration (14.5 g/dL) were significantly higher than those in group 2 (13.59 g/dL, p=0.003). Moreover, the difference in the mean hemoglobin levels before and after surgery for group 1 patients (3.55 g/dL) significantly exceeded that for group 2 patients (2.08 g/dL, p=0.000). Additional analysis revealed no statistically significant differences in perioperative complications between the groups.
Conclusions: Preoperative erythropoietin administration increased the safety margin of hemoglobin levels, and this strategy worked sufficiently well in our experience.
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Blood transfusion, Bloodless medical and surgical procedures, Erythropoietin, Jehovah¡¯s witnesses, Prostatectomy
KMID :
0358320140550020102
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